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Related Experiment Video

Updated: Nov 20, 2025

Postproduction Processing of Electrospun Fibres for Tissue Engineering

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Published on: August 9, 2012

Bioerosion of Synthetic Sling Explants.

Katherine E Washington¹, Gina Quiram², Angela Nguyen¹

¹Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, Texas 75080, United States.

ACS Biomaterials Science & Engineering

|January 20, 2021

Summary

Polypropylene (PP) midurethral slings degrade in vivo, showing bioerosion and oxidative damage over time. This research analyzes explanted PP slings to understand material changes in women with stress urinary incontinence.

Keywords:

oxidative degradation polypropylene sling mesh explant surgical mesh synthetic sling

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Published on: April 10, 2015

Area of Science:

Biomaterials Science
Urogynecology
Polymer Degradation

Background:

Midurethral slings made of polypropylene (PP) are used to treat stress urinary incontinence.
Concerns exist regarding the long-term biocompatibility and degradation of PP mesh implants in vivo.
Understanding material changes is crucial for patient outcomes and device development.

Purpose of the Study:

To investigate the in vivo degradation of polypropylene mesh explants from patients with stress urinary incontinence.
To characterize the changes in PP mesh material over time after implantation.

Main Methods:

Analysis of 10 explanted PP midurethral slings removed for adverse symptoms.
Use of scanning electron microscopy (SEM) for surface defect visualization.
Infrared spectroscopy (IR) and energy dispersive X-ray spectroscopy (EDX) to assess oxidative degradation.

Main Results:

Qualitative and quantitative evidence of bioerosion on the surface of PP explant samples.
Increased oxygen content detected in explants, indicating oxidative degradation.
SEM revealed surface defects consistent with material breakdown in vivo.

Conclusions:

Polypropylene mesh undergoes significant bioerosion and oxidative degradation within the human body.
These findings highlight the potential for material breakdown in PP slings used for stress urinary incontinence treatment.
Further research is needed to correlate degradation with clinical symptoms and long-term efficacy.