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Synthetic Spider Silk Production on a Laboratory Scale
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Progress and Trends in Artificial Silk Spinning: A Systematic Review
Andreas Koeppel1, Chris Holland1
1Department of Materials Science and Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, United Kingdom.
ACS Biomaterials Science & Engineering
|January 20, 2021
Summary
Researchers are developing artificial silks inspired by nature. This review compares artificial silk fiber spinning methods and properties, highlighting challenges in matching superior natural silks like spider dragline.
Area of Science:
- Biomimicry and Materials Science
- Protein-based Fiber Engineering
Background:
- Arthropods have evolved highly efficient protein-based fiber production over 400 million years.
- Natural silks, particularly spider dragline silk, exhibit exceptional properties inspiring artificial fiber development for over 80 years.
Purpose of the Study:
- To review various artificial silk fiber spinning approaches.
- To compare published artificial silk fiber properties against natural silks.
- To identify future trends and challenges in replicating high-performance natural silks.
Main Methods:
- Comprehensive literature review of artificial silk spinning techniques.
- Comparative analysis of mechanical and physical properties of reported artificial silk fibers.
- Benchmarking against properties of natural silks, including silkworm and spider dragline silks.
Main Results:
- Significant advancements in artificial silk production have led to fibers outperforming silkworm silks.
- Replicating the superior properties of dragline silks remains a key challenge.
- The review consolidates and compares a wide range of published fiber property data.
Conclusions:
- Artificial silk research is progressing, but matching elite natural silks requires further innovation.
- Understanding structure-property relationships is crucial for future high-performance artificial silk development.
- This work provides a roadmap for future research directions in artificial silk engineering.

