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Updated: Nov 20, 2025

Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
Circular RNAs: Potential Applications as Therapeutic Targets and Biomarkers in Breast Cancer
Debina Sarkar1, Sarah D Diermeier1
1Department of Biochemistry, University of Otago, Dunedin 9016, New Zealand.
Abstract:
Circular RNAs (circRNAs) are a class of non-coding RNAs that form a covalently closed loop. A number of functions and mechanisms of action for circRNAs have been reported, including as miRNA sponge, exerting transcriptional and translational regulation, interacting with proteins, and coding for peptides. CircRNA dysregulation has also been implicated in many cancers, such as breast cancer. Their relatively high stability and presence in bodily fluids makes cancer-associated circRNAs promising candidates as a new biomarker. In this review, we summarize the research undertaken on circRNAs associated with breast cancer, discuss circRNAs as biomarkers, and present circRNA-based therapeutic approaches.
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