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Full-Spectrum Targeted Mutagenesis in Plant and Animal Cells

Brian Iaffaldano1, Jakob Reiser1

  • 1Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, US Food and Drug Administration (FDA), Silver Spring, MD 20993, USA.

International Journal of Molecular Sciences
|January 20, 2021
PubMed
Summary

New hypermutation tools enable targeted DNA sequence diversity in plants and animals, advancing protein engineering and functional studies in higher organisms. These advancements promise broader applications in biological research and clinical settings.

Keywords:
CRISPRbase editingdirected evolutionhypermutationtargeted mutagenesis

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