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Updated: Nov 20, 2025

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

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Comorbidities at Diagnosis, Survival, and Cause of Death in Patients with Chronic Lymphocytic Leukemia: A

Alicia Villavicencio1,2,3, Marta Solans2,3,4, Lluís Zacarías-Pons5

  • 1Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Catalan Institute of Oncology, Carrer del Sol 15, 17004 Girona, Spain.

International Journal of Environmental Research and Public Health
|January 20, 2021
PubMed

Insights

Nearly all chronic lymphocytic leukemia (CLL) patients have comorbidities, which significantly impact survival. However, comorbidity

Area of Science:

  • Hematology
  • Oncology
  • Epidemiology

Background:

  • Chronic lymphocytic leukemia (CLL) is a common hematologic malignancy.
  • Comorbidities are frequent in CLL patients and can affect outcomes.
  • Understanding comorbidity burden is crucial for prognostic assessment in CLL.

Purpose of the Study:

  • To determine the prevalence of comorbidities in CLL patients.
  • To evaluate the influence of comorbidities on survival and mortality in CLL.
  • To assess comorbidity impact at a population-based level.

Main Methods:

  • Population-based cohort study of incident CLL cases (2008-2016) from Girona, Spain.
  • Comorbidities assessed using the Charlson Comorbidity Index (CCI) at diagnosis.
  • Observed (OS) and relative survival (RS) estimated; Cox models used for mortality analysis.

Main Results:

  • 99.5% of 400 CLL patients had at least one comorbidity; diabetes was most common.
  • 5-year OS and RS decreased with increasing CCI, notably for CCI ≥ 3.
  • Multivariate analysis showed no significant association between CCI and CLL-related or unrelated mortality when adjusting for age and Rai stage.

Conclusions:

  • High comorbidity burden negatively impacts OS and RS in CLL patients.
  • The statistical significance of comorbidity's effect on mortality is dependent on adjustment for other prognostic factors like age and Rai stage.
  • Comorbidity assessment is vital for comprehensive CLL patient management and prognostication.

Keywords:
causes of deathchronic lymphocytic leukemiacomorbiditiespopulation-basedsurvival

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