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Updated: Jun 23, 2026

An Allelotyping PCR for Identifying Salmonella enterica serovars Enteritidis, Hadar, Heidelberg, and Typhimurium

An Allelotyping PCR for Identifying Salmonella enterica serovars Enteritidis, Hadar, Heidelberg, and Typhimurium

Published on: July 22, 2011

Correlation Between Pathogenic Determinants Associated with Clinically Isolated Non-Typhoidal Salmonella.

Boimpoundi Eunice Flavie Ouali¹, Tsyr-Huei Chiou¹, Jenn-Wei Chen^2,3

¹Department of Life Sciences, National Cheng Kung University, Tainan City 701, Taiwan.

Pathogens (Basel, Switzerland)

|January 20, 2021

Summary

Salmonella bacteria cause significant global disease. This study explored virulence and genetic diversity in clinical isolates, revealing varied properties and highlighting the urgent need for updated antimicrobial resistance surveillance.

Keywords:

clinical isolates non-typhoidal Salmonella pathogenicity virulence factor

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Published on: August 9, 2022

Area of Science:

Microbiology
Infectious Diseases
Molecular Epidemiology

Background:

Salmonella species are major bacterial pathogens causing substantial worldwide disease burden.
While virulence factors of some Salmonella serovars are known, their overall pathogenesis and clinical symptom development remain underexplored.
Understanding isolate diversity is crucial for effective disease management.

Purpose of the Study:

To investigate the virulence traits and molecular diversity of clinical Salmonella isolates.
To correlate these properties with observed disease severity.
To assess antimicrobial susceptibility patterns of the isolates.

Main Methods:

Utilized microbiological and molecular procedures to analyze clinical Salmonella isolates.
Evaluated isolate virulence properties in relation to environmental factors and serotypes.
Determined antimicrobial susceptibility using disc diffusion and Minimum Inhibitory Concentration (MIC) assays.

Main Results:

Clinical Salmonella isolates exhibited diverse and sometimes conflicting virulence properties.
High susceptibility to Ceftriaxone (90%) was observed, with varying resistance to other antibiotics like Trimethoprim-Sulfamethoxazole (72%) and Ciprofloxacin (2%).
Emergence of multi-drug resistant isolates, including resistance to Trimethoprim-Sulfamethoxazole, Minocycline, Ampicillin, and Ceftazidime, was detected.

Conclusions:

Virulence in Salmonella is complex and influenced by isolate serotype and environmental factors.
Antimicrobial resistance patterns are shifting, necessitating careful treatment strategies.
Continuous microbiological and molecular surveillance is essential for tracking evolving endemic pathogens.