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Updated: Jul 3, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
In silico imaging clinical trials: cheaper, faster, better, safer, and more scalable
1Division of Imaging, Diagnostics, and Software Reliability, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, USA. aldo.badano@fda.hhs.gov.
Abstract:
Imaging clinical trials can be burdensome and often delay patient access to novel, high-quality medical devices. Tools for in silico imaging trials have significantly improved in sophistication and availability. Here, I describe some of the principal advantages of in silico imaging trials and enumerate five lessons learned during the design and execution of the first all-in silico virtual imaging clinical trial for regulatory evaluation (the VICTRE study).
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