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In Vitro Resistance and Evolution of Resistance to Tavaborole in Trichophyton rubrum
Diletta Mazzantini1, Francesco Celandroni1, Marco Calvigioni1
1Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Abstract:
Tavaborole is currently used in the topical treatment of onychomycosis. In this study, we analyzed the in vitro emergence/evolution of resistance against tavaborole in Trichophyton rubrum When T. rubrum strains were propagated on media containing the MIC of tavaborole, spontaneous resistant mutants were isolated at a frequency of 10-8 The frequency was almost 100-fold higher following fungal growth in the presence of a subinhibitory tavaborole concentration (0.5-fold the MIC) for 10 transfers. All collected mutants showed similar 4- to 8-fold increases in the drug MIC. No cross-resistance to other antifungals was evident.
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