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Inflammaging as a link between autoimmunity and cardiovascular disease: the case of rheumatoid arthritis

Pedro Santos-Moreno1, Gabriel Burgos-Angulo2, Maria Alejandra Martinez-Ceballos3

  • 1Rheumatology, Biomab IPS, Bogota, Colombia pedrosantosmoreno@hotmail.com.

RMD Open
|January 20, 2021
PubMed

Insights

Individuals with autoimmune diseases experience accelerated vascular aging due to chronic inflammation, increasing cardiovascular disease risk. Treatments for rheumatoid arthritis show cardiovascular benefits, suggesting new therapeutic avenues.

Area of Science:

  • Cardiovascular Disease Research
  • Immunology
  • Gerontology

Background:

  • Cardiovascular disease (CVD) risk factors include age and inflammation.
  • Inflammaging describes age-related chronic inflammation, accelerating vascular remodeling and atherogenesis.
  • Autoimmune diseases involve chronic inflammation, potentially leading to premature vascular aging.

Purpose of the Study:

  • To explore the link between autoimmune diseases and accelerated vascular aging.
  • To investigate the impact of autoimmunity on cardiovascular health.
  • To assess the cardiovascular benefits of rheumatoid arthritis treatments.

Main Methods:

  • Review of traditional and non-traditional CVD risk factors.
  • Analysis of the role of inflammation and inflammaging in vascular aging.
  • Evaluation of non-invasive cardiovascular tests like pulse wave velocity.
  • Examination of treatment impacts on rheumatoid arthritis patients' cardiovascular health.

Main Results:

  • Autoimmune diseases are associated with accelerated vascular aging and increased CVD risk.
  • Chronic inflammation in autoimmunity contributes to vascular stiffness.
  • Rheumatoid arthritis treatments demonstrate positive cardiovascular effects.

Conclusions:

  • Autoimmunity accelerates vascular aging, increasing cardiovascular morbidity and mortality.
  • Targeting inflammation in autoimmune diseases may mitigate cardiovascular risks.
  • Pharmacotherapy for rheumatoid arthritis offers potential cardiovascular benefits.

Keywords:
arthritisautoimmune diseasescardiovascular diseasesinflammationrheumatoid

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