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Related Experiment Videos

Typological prediction of response to amitriptyline: a replication study.

B A Prusoff, E S Paykel

    International Pharmacopsychiatry
    |January 1, 1977
    PubMed
    Summary

    This study replicated depression typologies, finding anxious depressives responded poorly to amitriptyline. Hostile and young depressives with personality disorder showed the best outcomes, validating depression subtypes.

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    Area of Science:

    • Psychiatry
    • Clinical Psychology
    • Psychopharmacology

    Background:

    • Depression is a heterogeneous disorder.
    • A cluster analysis previously identified four depression subtypes.
    • Understanding these subtypes may predict treatment response.

    Purpose of the Study:

    • To replicate the predictive validity of a four-group depression typology.
    • To examine treatment outcomes for different depression subtypes.
    • To further validate the heterogeneity of nonpsychotic depression.

    Main Methods:

    • Replication study involving 143 acutely depressed women.
    • Treatment with amitriptyline for 4 weeks.
    • Analysis of treatment response based on depression typology.

    Main Results:

    • Anxious depressives exhibited the poorest response to amitriptyline.
    • Hostile depressives and young depressives with personality disorder showed the best response.
    • Psychotic depressives had an intermediate treatment response.

    Conclusions:

    • The findings provide further validation for the four-group depression typology.
    • The results support the view that nonpsychotic depression is heterogeneous.
    • Depression subtypes appear to predict differential treatment outcomes.

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