[Two Cases of Breast Cancer with Extensive Invasion to Skin]

Case 1: A 48-year-old female was admitted to our hospital because of left HER2 type breast cancer with a skin invasion of 10×11 cm in the chest wall. Since she had previously received anti-HER2 therapy, we performed anti-HER2 therapy in our department as well, but the tumor gradually became larger and presented with a cancerous ulcer. The use of metronidazole gel in the tumor area reduced the odor. The tumor progressed and she died 1 year and 1 month after the first visit to our hospital. Case 2: A 51-year-old female visited our hospital because of a cauliflower-like right breast tumor measuring 20×17 cm with bleeding and infection. After diagnosis of right breast cancer with multiple bone metastasis, CMF therapy was performed, and then 40 cycles of docetaxel and bevacizumab therapy were performed. As a result, her breast tumor is no longer visible macroscopically, and she runs her daily life without problems. Breast cancer with an extensive skin invasion has a poor prognosis. However, in some cases such as case 2, the proper chemotherapy might be beneficial for long survival.