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Association Between Systemic Immune-Inflammation Index and Diabetic Depression
Jie Wang1, Depu Zhou1, Zhijuan Dai2
1Department of Endocrinology, Yanbian University Hospital, Yanji, Jilin, People's Republic of China.
Clinical Interventions in Aging
|January 20, 2021
Summary
High systemic immune-inflammation (SII) index is linked to depression in diabetes patients. This easily accessible marker may help identify diabetic depression, warranting further research.
Area of Science:
- Endocrinology
- Psychiatry
- Immunology
Background:
- Depression is common in diabetes mellitus (DM) patients.
- Diabetic depression is associated with low-grade systemic inflammation.
- The systemic immune-inflammation (SII) index is a novel inflammatory indicator.
Purpose of the Study:
- Investigate the relationship between diabetic depression and SII levels.
- Adjust for potential confounding factors in this association.
- Examine SII's predictive potential for diabetic depression.
Main Methods:
- Cross-sectional study using National Health and Nutrition Examination Survey data (2009-2016).
- Calculated SII index: (platelet count × neutrophil count) / lymphocyte count.
- Used Patient Health Questionnaire-9 for depression assessment; employed multivariable logistic regression and propensity score-matched analysis.
Main Results:
- Included 2566 diabetes mellitus patients; 13.3% diagnosed with depression.
- High SII level independently predicted diabetic depression (OR = 1.347, P = 0.02882).
- Propensity score-matched analysis confirmed the association between SII and diabetic depression.
Conclusions:
- Systemic immune-inflammation (SII) index is a risk factor for depression in diabetes patients.
- SII may serve as a cost-effective tool for identifying depression in this population.
- Further research is needed to fully elucidate SII's role in diabetic depression.
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