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Updated: Nov 20, 2025
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A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
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(Pro)renin receptor in the kidney: function and significance
Gertrude Arthur1, Jeffrey L Osborn2, Frédérique B Yiannikouris1
1Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky.
Summary
The (Pro)renin receptor (PRR) is multifunctional in the kidney, regulating fluid balance, blood pressure, and acid-base homeostasis. It also plays a role in kidney diseases like hypertension and fibrosis.
Area of Science:
- Nephrology
- Molecular Biology
- Cell Biology
Background:
- The (Pro)renin receptor (PRR) is a multifunctional protein involved in the renin-angiotensin system (RAS).
- PRR is abundant in the kidney, particularly in the cortical collecting duct.
- It is also a component of the vacuolar H+-ATPase, participating in autophagy.
Purpose of the Study:
- To review the diverse roles of PRR in kidney development and function.
- To highlight PRR's involvement in body fluid volume homeostasis, blood pressure regulation, and acid-base balance.
- To explore novel molecular mechanisms of PRR in renal health and disease.
Main Methods:
- Literature review focusing on PRR's established and emerging functions.
- Analysis of PRR's role in different kidney cell types (macula densa, podocytes, tubules, collecting duct).
- Exploration of PRR's involvement in physiological and pathophysiological processes.
Main Results:
- PRR is crucial for water and salt balance, acid-base regulation, and autophagy in the kidney.
- PRR contributes to the development and progression of hypertension, diabetic retinopathy, and kidney fibrosis.
- PRR influences kidney function across various cellular components.
Conclusions:
- PRR is a key regulator of renal homeostasis and a significant factor in kidney pathophysiology.
- Understanding PRR's molecular mechanisms is vital for addressing renal diseases.
- This review provides insights into PRR's multifaceted roles in the kidney.
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