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Review article: safety of new biologic agents for inflammatory bowel disease in the liver

Salvatore Magrì1, Luchino Chessa2, Mauro Demurtas3

  • 1Department of Endoscopic Surgery, 'G.Brotzu' Hospital, Piazzale Alessandro Ricchi, Cagliari.

European Journal of Gastroenterology & Hepatology
|January 20, 2021
PubMed

Insights

New biologic therapies for inflammatory bowel diseases, including vedolizumab, ustekinumab, and tofacitinib, show promise but raise concerns regarding liver function, especially in patients with pre-existing liver conditions.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Pharmacology

Background:

  • New biologic agents like vedolizumab, ustekinumab, and tofacitinib are approved for inflammatory bowel diseases.
  • Concerns exist regarding the hepatic safety of these advanced therapies, particularly in specific patient populations.

Purpose of the Study:

  • To review available data on the liver safety of vedolizumab, ustekinumab, and tofacitinib.
  • To assess the safety of these agents in patients with and without pre-existing liver diseases.

Main Methods:

  • Literature review of safety data for vedolizumab, ustekinumab, and tofacitinib.
  • Focus on hepatic safety in patients with hepatitis B, hepatitis C, cirrhosis, and transplant recipients.

Main Results:

  • Limited data exist on vedolizumab efficacy in primary sclerosing cholangitis.
  • These agents have been associated with drug-induced liver injury.
  • Hepatic safety data in patients with pre-existing liver conditions are scarce.

Conclusions:

  • Further research is needed to fully understand the hepatic safety profile of these new biologic agents.
  • Careful monitoring is essential for patients with pre-existing liver conditions receiving these treatments.

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