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Updated: Nov 20, 2025
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Effects of site, cerebral perfusion and degree of cerebral artery stenosis on cognitive function
Binbin Xie1, Yidan Liu, DongMei Wu
1Department of Neurology, The second affiliated hospital of Chongqing Medical University, Chongqing, China.
Insights
Cerebral artery stenosis (CAS) impairs cognitive functions like memory and executive function, particularly with anterior circulation stenosis, moderate to severe stenosis, and low cerebral perfusion. These findings highlight the impact of CAS on brain health.
Area of Science:
- Neurology
- Neuroscience
- Vascular Neurology
Background:
- Cerebral artery stenosis (CAS) is a significant risk factor for cerebrovascular events.
- Cognitive impairment is a common complication of various neurological conditions.
- Understanding the specific impact of CAS on cognitive function is crucial for patient management.
Purpose of the Study:
- To investigate the effects of the location, cerebral perfusion, and severity of cerebral artery stenosis (CAS) on cognitive function.
- To identify specific cognitive domains affected by CAS.
- To explore the relationship between CAS characteristics and cognitive performance.
Main Methods:
- A cohort study included 57 patients with CAS and 53 controls.
- Patients with CAS were subgrouped based on stenosis site, cerebral perfusion, and degree.
- Neuropsychological tests assessed cognitive domains including memory, executive function, and psychomotor speed.
- Statistical analyses included rank sum test, t-test, Chi-square, ANOVA, and Spearman correlation.
Main Results:
- Patients with CAS and reduced cerebral perfusion showed significant impairments in global cognitive function, memory, psychomotor speed, executive function, and frontal lobe function (P < 0.05).
- Anterior circulation stenosis was associated with significant decreases in global cognitive function, psychomotor speed, memory, executive function, and frontal lobe function (P < 0.05).
- Moderate and severe CAS significantly impaired global cognitive function, memory, psychomotor speed, executive function, and frontal lobe function (P < 0.05).
- A significant correlation was found between CAS site, cerebral perfusion, degree of stenosis, and cognitive function scores.
Conclusions:
- CAS negatively impacts global cognitive function, memory, psychomotor speed, frontal lobe function, and executive function.
- These cognitive deficits are more pronounced in cases of anterior circulation stenosis, moderate to severe stenosis, and low cerebral perfusion.
- The findings underscore the importance of considering CAS characteristics in the assessment and management of cognitive decline.
Objective:
To investigate the effects of site, cerebral perfusion and degree of cerebral artery stenosis (CAS) on cognitive function.
Methods:
A total of 57 patients with CAS and 53 controls from January 2019 to December 2019 were included. The former group was further divided into different subgroups according to the site, cerebral perfusion and degree of CAS. A series of neuropsychological tests were performed to evaluate the cognitive domains (such as memory, executive function, psychomotor speed, etc.). Rank sum test, t test, Chi-square test and analysis of variance were used for data analysis. Spearman correlation analysis was used to examine the relationship between the site, cerebral perfusion and degree of CAS and all tests' scores.
Results:
For patients with CAS who have decreased cerebral perfusion, their global cognitive function, memory, psychomotor speed, executive function and frontal lobe function were significantly impaired (all P < 0.05). There was a significant decrease in global cognitive function, psychomotor speed, memory, executive function and frontal lobe function in patients with anterior circulation stenosis (all P < 0.05). Moderate and severe CAS impaired subjects' global cognitive function, memory, psychomotor speed, executive function and frontal lobe function (all P < 0.05). There was a correlation between the site, cerebral perfusion, the degree of CAS and cognitive function.
Conclusion:
Global cognitive function, memory, psychomotor speed, frontal lobe function and executive function are impaired in patients with CAS, especially in those with anterior circulatory stenosis, moderate to severe stenosis and low cerebral perfusion.See Video Abstract, http://links.lww.com/WNR/A613.
