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Updated: Nov 20, 2025
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Homogeneous Time-resolved Förster Resonance Energy Transfer-based Assay for Detection of Insulin Secretion
Published on: May 10, 2018
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RESULTS OF A 24-WEEK TRIAL OF TECHNOSPHERE INSULIN VERSUS INSULIN ASPART IN TYPE 2 DIABETES
Byron J Hoogwerf1, Kevin M Pantalone2, Marina Basina3
1Department of Endocrinology, Diabetes, and Metabolism (Emeritus), Cleveland, Ohio.
Summary
Technosphere insulin (TI) and insulin aspart (IA) both effectively reduced HbA1C in type 2 diabetes patients. TI also led to significant weight loss, supporting its use as a treatment option.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Pharmacology
Background:
- Type 2 diabetes management requires effective glycemic control.
- Basal insulin therapy is common, but additional prandial insulin may be needed.
- Comparing different prandial insulin options is crucial for optimizing patient outcomes.
Purpose of the Study:
- To compare the glycemic efficacy of Technosphere insulin (TI) versus insulin aspart (IA).
- Both insulins were administered as an addition to basal insulin therapy.
- The study aimed to evaluate TI and IA in individuals with type 2 diabetes.
Main Methods:
- A randomized, 24-week clinical trial was conducted.
- Participants had type 2 diabetes and were treated with subcutaneous insulin.
- Subjects were randomized to receive either TI or IA, added to stabilized insulin glargine.
Main Results:
- Both TI and IA groups achieved significant reductions in HbA1C levels.
- The difference in HbA1C reduction between TI and IA was not statistically significant, but did not meet the predefined equivalence margin.
- Subjects treated with TI experienced significant weight loss compared to those treated with IA.
Conclusions:
- Technosphere insulin and insulin aspart provide clinically meaningful HbA1C reductions.
- Technosphere insulin offers an additional benefit of significant weight reduction.
- Inhaled insulin, such as TI, is a viable treatment option for type 2 diabetes management.
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