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Updated: Nov 20, 2025
Isolation and Characterization of Human Umbilical Cord-derived Mesenchymal Stem Cells from Preterm and Term Infants
Published on: January 26, 2019
Umbilical Cord Management in Late Preterm and Term Infants: A Randomized Controlled Trial
Hasan Kilicdag1, Barbaros Sahin Karagun2, Ali Bulent Antmen2
1Department of Pediatrics, Division of Neonatology, Acibadem Mehmet Ali Aydınlar University School of Medicine, Istanbul, Turkey.
Objective:
The study aimed to compare the effects of three different methods of umbilical cord management on hematological parameters in term and late-preterm infants.
Study Design:
A randomized controlled trial comparing intact-umbilical cord milking (I-UCM) with cut-umbilical cord milking (C-UCM) and immediate cord clamping (ICC) in neonates born >35 weeks' gestation.
Results:
A total of 587 infants were evaluated. Of these, 197 were assigned to I-UCM, 190 to C-UCM, and 200 to ICC. Mean hemoglobin and hematocrit levels at 48 hours of age were higher in I-UCM group compared with the ICC group (p = 0.002 and p = 0.010, respectively).
Conclusion:
These findings suggest that I-UCM is more beneficial choice. Further trials are needed to assess the various long- and short-term effects of different cord milking methods.
Key Points:
· This is the first study comparing these three methods (I-UCM, C-UCM, and ICC) concurrently.. · I-UCM is more beneficial choice.. · Although the terms I-UCM and C-UCM are often used interchangeably, these are different procedures..
