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Staging model for amyotrophic lateral sclerosis in Singapore
Yuan Teck Tay1, Josiah Y H Chai2, Kamilah Bte Shekh Jabin2
1Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Singapore Medical Journal
|January 21, 2021
Summary
King's staging effectively models amyotrophic lateral sclerosis (ALS) progression in Singapore. This clinical staging aids physicians in timely management of patient needs and symptoms.
Area of Science:
- Neurology
- Clinical Medicine
- Disease Staging
Background:
- Amyotrophic lateral sclerosis (ALS) management requires a staging model to address evolving patient needs.
- Existing staging systems need validation in diverse populations.
Purpose of the Study:
- To assess the clinical trajectory of ALS in Singapore.
- To evaluate the congruity of King's College staging for ALS (King's staging) in Singaporean patients.
Main Methods:
- Retrospective cohort study of 46 ALS patients in Singapore.
- Utilized King's staging criteria: symptom onset, diagnosis, central nervous system (CNS) region involvement, supportive feeding, and ventilation.
- Measured standardized timings from disease onset to death.
Main Results:
- King's staging showed significant congruity with the clinical course of ALS in Singapore.
- Limb-onset ALS: diagnosis (0.35), two CNS regions (0.42), three CNS regions (0.63), diaphragmatic (0.81), bulbar (0.73).
- Bulbar-onset ALS: diagnosis (0.14), two CNS regions (0.28), three CNS regions (0.42), diaphragmatic (0.62), bulbar (0.67).
Conclusions:
- King's staging is a viable model for predicting ALS trajectory in Singapore.
- Accessible ALS staging facilitates prompt and effective patient care.
Keywords:
Amyotrophic lateral sclerosismotor neuron diseaseneurodegenerative diseaseprognosisstaging model
