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Updated: Nov 20, 2025
A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
Endothelial cell density change in fully dislocated XEN Gel IMPLANT after trabeculectomy: A case report
Martina Menchini1, Francesco Sartini1, Filippo Tatti2
1Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Purpose:
To report a case of fully dislocated XEN Gel Implant device into the anterior chamber, 18 months after its implantation and its impact on endothelial cell density.
Result:
A 75-year-old man with a history of multiple glaucoma surgeries during the last three years presented with an entirely dislocated XEN Gel implant into the anterior chamber. An endothelial cell density reduction was observed over 18 months. Thus, the implant was removed. In the short-term after surgery, the endothelial cell loss rate reduced.
Conclusion:
XEN Gel Implant can dislocate into the anterior chamber, increasing endothelial cell loss in an eye already underwent multiple surgical procedures with subsequent adverse events. Therefore, if the implant seems displaced, the endothelial cell density should be monitored, and the length of the free-tube segment within the anterior chamber should be measured, during the patient's follow-up.
