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Staphylococcus-associated acute glomerulonephritis in a patient with dermatomyositis
Rasmi Ranjan Sahoo1, Sourav Pradhan1, Akhil Pawan Goel1
1Department of Clinical Immunology and Rheumatology, King George's Medical University, Lucknow, Uttar Pradesh, India.
BMJ Case Reports
|January 21, 2021
Summary
Staphylococcus-associated glomerulonephritis (SAGN) can complicate dermatomyositis (DM). Early diagnosis and treatment of staphylococcal sepsis are crucial for managing kidney injury and preventing fatal outcomes like infective endocarditis.
Area of Science:
- Nephrology
- Rheumatology
- Infectious Diseases
Background:
- Dermatomyositis (DM) is an autoimmune disease that can be associated with glomerulonephritis.
- Staphylococcus-associated glomerulonephritis (SAGN) is a kidney disease complication arising from staphylococcal infections.
Observation:
- A 40-year-old male with DM presented with acute kidney injury, initially treated with corticosteroids.
- Kidney biopsy revealed SAGN alongside Staphylococcus bacteraemia and septic arthritis of the knee.
Findings:
- The patient received intravenous immunoglobulin, reduced steroids, and intravenous vancomycin for the infection.
- Despite initial improvement, the patient developed infective endocarditis and died from congestive heart failure.
Implications:
- Undiagnosed staphylococcal sepsis can significantly worsen the prognosis in patients with rheumatological conditions like DM.
- Prompt identification and management of underlying infections are critical to reduce morbidity and mortality in complex cases.
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