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Gadolinium Deposition: A Study Review.

Sean E Strickler¹, Kevin R Clark²

¹Associate instructor for Emory University's medical imaging program in Atlanta, Georgia. He recently completed his graduate studies in radiologic science education from Midwestern State University in Wichita Falls, Texas.

Radiologic Technology

|January 21, 2021

Summary

This summary is machine-generated.

Gadolinium-based contrast agents (GBCAs) can deposit in tissues, with less stable agents accumulating more. Medical imaging professionals must weigh risks and benefits, especially for patients with renal insufficiency, and consider alternative imaging techniques.

Keywords:

MR imaging deposition gadolinium-based contrast agents linear macrocyclic radiology retention

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Area of Science:

Radiology
Medical Imaging
Neuroimaging

Background:

Gadolinium-based contrast agents (GBCAs) are widely used in magnetic resonance (MR) imaging.
Concerns exist regarding gadolinium deposition in tissues, including the brain.
The long-term clinical significance of retained gadolinium is not fully understood.

Purpose of the Study:

To review literature on gadolinium deposition and retention.
To inform medical imaging professionals about potential risks associated with GBCAs.
To explore alternative imaging techniques that minimize or eliminate the need for GBCAs.

Main Methods:

Systematic literature search of PubMed, Academic Search Complete, and Science Direct.
Inclusion of MR textbook information and organizational reports.
Analysis of data on GBCA classifications, risks, deposition rates, and alternatives.

Main Results:

Nonionic linear GBCAs show higher tissue accumulation rates compared to ionic macrocyclic agents.
More stable macrocyclic agents result in lower levels of gadolinium deposition.
Current literature focuses on GBCA risks, deposition, recommendations, and alternative techniques.

Conclusions:

MR technologists must assess patient renal function and select appropriate GBCAs according to guidelines.
The clinical impact of gadolinium retention in the brain requires further long-term investigation.
Case-by-case decisions are crucial for patients at risk, balancing risks and benefits, and minimizing GBCA use when possible.