Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

376
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
376

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A consensus statement on dual purpose pathogen surveillance systems: The always on approach.

PLOS global public health·2024
See all related articles

Related Experiment Video

Updated: Nov 20, 2025

Author Spotlight: Development of Simplified CRISPR-Based Tests for Rapid Detection of Infectious Diseases
10:16

Author Spotlight: Development of Simplified CRISPR-Based Tests for Rapid Detection of Infectious Diseases

Published on: August 16, 2024

1.7K

Precision Pandemic Preparedness: Improving Diagnostics with Metagenomics.

Kumeren N Govender1,2,3

  • 1Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom kumeren.govender@ndm.ox.ac.uk.

Journal of Clinical Microbiology
|January 21, 2021
PubMed
Summary

Clinical metagenomics offers a scalable advantage for early detection of unknown infectious disease threats in routine laboratories. This approach aids pandemic preparedness and can improve patient outcomes despite existing challenges.

Keywords:
diagnosisdisease outbreaksinfectionmetagenomics

More Related Videos

High-throughput Detection of Respiratory Pathogens in Animal Specimens by Nanoscale PCR
11:00

High-throughput Detection of Respiratory Pathogens in Animal Specimens by Nanoscale PCR

Published on: November 28, 2016

12.2K
Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling
08:26

Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling

Published on: June 23, 2022

1.9K

Related Experiment Videos

Last Updated: Nov 20, 2025

Author Spotlight: Development of Simplified CRISPR-Based Tests for Rapid Detection of Infectious Diseases
10:16

Author Spotlight: Development of Simplified CRISPR-Based Tests for Rapid Detection of Infectious Diseases

Published on: August 16, 2024

1.7K
High-throughput Detection of Respiratory Pathogens in Animal Specimens by Nanoscale PCR
11:00

High-throughput Detection of Respiratory Pathogens in Animal Specimens by Nanoscale PCR

Published on: November 28, 2016

12.2K
Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling
08:26

Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling

Published on: June 23, 2022

1.9K

Area of Science:

  • Infectious Diseases
  • Genomics
  • Public Health

Background:

  • Future pandemics pose an ongoing global health security threat.
  • Early detection of novel infectious agents is crucial for effective response.
  • Routine clinical laboratories can play a role in identifying emerging threats.

Purpose of the Study:

  • To assess the feasibility and scalability of clinical metagenomics for early detection of unknown infectious threats.
  • To evaluate the potential of clinical metagenomics in routine care settings.
  • To highlight the role of metagenomics in enhancing pandemic preparedness.

Main Methods:

  • Utilizing metagenomic sequencing techniques on clinical samples.
  • Developing and validating protocols for identifying complex infectious diseases.
  • Analyzing data to detect known and unknown pathogens.

Main Results:

  • Clinical metagenomics demonstrates feasibility and scalability for routine laboratory use.
  • The approach can identify complicated infectious diseases, aiding diagnosis.
  • Early detection of threats is achievable through this methodology.

Conclusions:

  • Clinical metagenomics provides a significant advantage for early detection of novel pandemic threats.
  • Implementation in routine care can improve patient outcomes and pandemic preparedness.
  • Addressing technical and regulatory challenges is necessary for widespread adoption.