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Influential factors for large volume of spontaneous supratentorial intracerebral hemorrhage
Meishan Xiong1, Sai Wang2, Yupeng Zhang2
1Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China. 476359069@qq.com.
Objectives:
To explore the relevant protective and risk factors that affect spontaneous supratentorial large volume intracerebral hemorrhage.
Methods:
Clinical data of hospitalized patients with spontaneous supratentorial intracerebral hemorrhage in Xiangya Hospital of Central South University from January 2014 to December 2018 were retrospectively analyzed. According to the amount of intracerebral hemorrhage (≥30 mL), the patients were divided into a large volume intracerebral hemorrhage group (255 cases) and a non-large volume intracerebral hemorrhage group (397 cases). Univariate and multivariate logistic regression analysis for the clinical data from the two groups of patients were performed.
Results:
Systolic blood pressure, diastolic blood pressure, white blood cell count, neutrophil count, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein cholesterol, calcium ion concentration, and international standard ratio between the large volume intracerebral hemorrhage group and the non-large volume intracerebral hemorrhage group were significantly different (all P<0.05). Multivariate logistic regression analysis showed the increased LDL cholesterol (OR=0.709, 95% CI 0.564 to 0.892, P=0.003) and the increased calcium concentration (OR=0.084, 95% CI 0.023 to 0.309, P<0.001) were the protective factors for large volume intracerebral hemorrhage on the screen; while the increased white blood cell count (OR=1.268, 95% CI 1.194 to 1.347, P<0.001), the increased high-density lipoprotein cholesterol (OR=1.884, 95% CI 1.199 to 2.961, P=0.006), the increased systolic blood pressure at admission (OR=1.022, 95% CI 1.014 to 1.030, P<0.001), and the increased international standard ratio (OR=26.209, 95% CI 4.712 to 145.764, P<0.001) were the risk factors.
Conclusions:
The occurrence of spontaneous supratentorial large volume intracerebral hemorrhage is the result of combination of multiple factors. The increased white blood cell count, the increased systolic blood pressure, the increased high-density lipoprotein cholesterol, and the increased international standard ratio may increase its risk, while the increased LDL cholesterol and calcium concentration may reduce its risk.
