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Research advances in add-on treatment for negative symptoms and cognitive dysfunction in schizophrenia
Ranran Li1, Gangrui Hei2, Ye Yang2
1Department of Psychiatry, Shandong Mental Health Center, Jinan 250014. dtlrr113@126.com.
Abstract:
Antipsychotic medication is the primary treatment for schizophrenia, which is effective on ameliorating positive symptoms and can reduce the risk of recurrence, but it has limited efficacy for negative symptoms and cognitive dysfunction. The negative symptoms and cognitive dysfunction seriously affects the life quality and social function for the patients with schizophrenia. Currently, there is plenty evidence that antipsychotic drugs combined with adjuvant therapy drugs can effectively improve the negative symptoms and cognitive dysfunction. These drugs include anti-oxidants, nicotinic acetylcholine receptors and neuro-inflammatory drugs (anti-inflammatory drugs, minocycline), which show potential clinical effects.
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