Catalytic enantioselective C(sp3)-H functionalization involving radical intermediates
Chi Zhang1, Zhong-Liang Li2, Qiang-Shuai Gu3
1Shenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, 518055, Shenzhen, China.
Nature Communications
|January 21, 2021
Summary
Enantioselective functionalization of C(sp3)-H bonds using radical chemistry is advancing. This perspective reviews catalytic methods for controlling stereochemistry in radical reactions and highlights future research directions.
Area of Science:
- Organic Chemistry
- Catalysis
- Radical Chemistry
Background:
- Radical chemistry has seen significant advancements, leading to new methods for C(sp3)-H bond functionalization.
- Enantioselective synthesis is crucial for developing chiral molecules, particularly in pharmaceuticals.
Purpose of the Study:
- To provide a comprehensive overview of catalytic enantioselective C(sp3)-H functionalization using radical intermediates.
- To discuss the current state-of-the-art, challenges, and future opportunities in this rapidly developing field.
Main Methods:
- This perspective focuses on catalytic approaches for enantioselective C(sp3)-H functionalization.
- It analyzes strategies based on the timing of stereochemistry determination: during radical formation or functionalization.
Main Results:
- Recent progress has revitalized the field of radical-mediated enantioselective C(sp3)-H functionalization.
- Two primary catalytic modes exist, differing in when stereochemistry is established.
Conclusions:
- Catalytic enantioselective C(sp3)-H functionalization via radical pathways offers significant potential.
- Further research is needed to address challenges and unlock new opportunities in this area.
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