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Fisetin: An anticancer perspective.

Muhammad Imran1, Farhan Saeed2, Syed Amir Gilani1

  • 1Faculty of Allied Health Sciences University Institute of Diet and Nutritional Sciences The University of Lahore Lahore Pakistan.

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|January 21, 2021
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Summary
This summary is machine-generated.

Fisetin, a dietary polyphenol found in fruits and vegetables, exhibits potent anticancer properties by inhibiting cancer cell proliferation, invasion, and growth. This review highlights fisetin

Keywords:
anticancerbreast cancerchemopreventive agentfisetinflavonoids

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Area of Science:

  • Phytochemistry
  • Molecular Biology
  • Oncology

Background:

  • Dietary phytochemicals show promise in cancer chemoprevention.
  • Fisetin (3,3',4',7-tetrahydroxyflavone) is a flavonoid found in various fruits and vegetables.
  • Enhancing the efficacy of existing cancer prevention strategies is crucial.

Purpose of the Study:

  • To review and discuss the anticancer role of fisetin.
  • To highlight fisetin's mechanisms of action against cancer cells.
  • To evaluate fisetin's potential in cell culture, animal, and human studies.

Main Methods:

  • Literature review of studies on fisetin's anticancer effects.
  • Analysis of fisetin's impact on cancer cell proliferation, invasion, and apoptosis.
  • Investigation of fisetin's modulation of signaling pathways (e.g., PKCα/ROS/ERK1/2, p38 MAPK, NF-κB) and protein expression (e.g., securin, TET1).

Main Results:

  • Fisetin inhibits cancer cell proliferation, invasion, and growth.
  • Fisetin induces apoptosis and poly (ADP-ribose) polymerase (PARP) cleavage.
  • Fisetin modulates key cancer-related signaling pathways and protein expressions, including TET1 and securin.

Conclusions:

  • Fisetin, a polyphenol with pleiotropic pharmacological properties, demonstrates significant anticancer activity across various cancer types.
  • Fisetin effectively suppresses cancer cell progression, cell cycle, and growth, while inducing apoptosis.
  • Fisetin holds promise as a chemopreventive agent for a wide range of cancers.