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D-dimer levels is associated with severe COVID-19 infections: A meta-analysis
Wei-Na Du1, Ying Zhang2, Yong Yu2
1Department of Critical Care Medicine, Huantai County People's Hospital, Zibo, China.
International Journal of Clinical Practice
|January 21, 2021
Summary
Elevated D-dimer levels are significantly associated with COVID-19 severity. Severe coronavirus disease 2019 patients exhibit higher D-dimer concentrations, offering potential clinical insights.
Area of Science:
- Medical Research
- Hematology
- Infectious Diseases
Background:
- The COVID-19 pandemic, caused by SARS-CoV-2, presents complex clinical manifestations.
- Abnormal D-dimer concentrations in COVID-19 patients have been observed, but their significance remains debated.
Approach:
- A comprehensive meta-analysis was conducted to investigate the relationship between D-dimer levels and COVID-19.
- Systematic literature search using MASH terms and predefined inclusion/exclusion criteria was performed.
Key Points:
- A significant association was found between D-dimer concentration and COVID-19.
- The pooled odds ratio (OR) was 1.90 (95% CI: 1.32-2.48), indicating increased odds of COVID-19 with elevated D-dimer.
- Sensitivity analysis confirmed the robustness of the findings, with no evidence of publication bias.
Conclusions:
- D-dimer concentration is significantly related to the severity of COVID-19.
- Severe COVID-19 cases tend to present with higher D-dimer levels compared to non-severe cases.
- These findings may aid in the clinical management and risk stratification of COVID-19 patients.
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