Synbiotics supplement is effective for Melasma improvement

Area of Science:

• Dermatology
• Microbiology
• Nutraceuticals

Background:

• Melasma is a common skin hyperpigmentation disorder requiring multifaceted treatment approaches.
• Probiotics show potential in managing skin conditions due to anti-inflammatory and antioxidant properties.
• Synbiotics may offer benefits for melasma by influencing melanogenesis and skin health.

Purpose of the Study:

• To evaluate the efficacy of oral synbiotics in improving melasma severity.
• To assess changes in melasma area and severity index (MASI) scores.
• To investigate the impact of synbiotics on skin health in melasma patients.

Main Methods:

• A 12-week, double-blind, randomized controlled trial was conducted with 57 participants.
• Participants (aged 30-50, Fitzpatrick skin types III-VI) received either oral synbiotics or a placebo daily.
• Melasma severity was assessed using the modified Melasma Area and Severity Index (mMASI) at baseline and weeks 4, 8, and 12.

Main Results:

• The synbiotics group showed a significant reduction in mMASI scores compared to the placebo group at week 12 (P = .008).
• Melasma severity scores consistently decreased in the synbiotics group throughout the study period.
• No significant changes were observed in the placebo group's melasma severity scores.

Conclusions:

• Oral synbiotics supplementation effectively improves melasma severity.
• Synbiotics represent a promising therapeutic option for managing melasma.
• Further research can explore long-term effects and optimal dosages of synbiotics for hyperpigmentation.