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Updated: Nov 20, 2025
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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Electrochemical Desulfurative Cyclization Accessing Oxazol-2-amine Derivatives via Intermolecular C-N/C-O Bond
Jinhui Hu1, Huanliang Hong1, Yongwei Qin1
1School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529090, P. R. China.
Abstract:
A practical protocol has been established to access diverse oxazol-2-amine derivatives in one step via the electrochemical desulfurative cyclization of isothiocyanates and α-amino ketones. On the basis of the cycle of in situ generation of iodine/desulfurative cyclization/iodide anion regeneration, the reaction is performed under metal-free and external-oxidant-free electrolytic conditions to achieve the formation of intermolecular C-O and C-N bonds, providing oxazol-2-amines in moderate to excellent yields.
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