Childhood Core Binding Factor (CBF) acute myeloid leukaemia and its association with French American British (FAB)
Naeem Jabbar1, Neelum Mansoor2, Sidra Maqsood3
1Department Pediatric Oncology, Indus Health Network, Karachi, Pakistan.
Insights
Core binding factor acute myeloid leukaemia occurs in 34% of pediatric cases. This study found a significant association between core binding factor and specific acute myeloid leukaemia subtypes in children.
Area of Science:
- Hematology
- Pediatric Oncology
- Clinical Genetics
Background:
- Acute myeloid leukaemia (AML) is a heterogeneous group of cancers.
- Core binding factor (CBF) rearrangements are common genetic alterations in AML.
- Understanding the frequency and associations of CBF-AML is crucial for prognosis and treatment.
Purpose of the Study:
- To determine the frequency of core binding factor acute myeloid leukaemia (CBF-AML) in a pediatric population.
- To investigate the association between CBF-AML and morphological subtypes of AML.
Main Methods:
- A retrospective study analyzed data of pediatric patients (1-17 years) diagnosed with AML between July 2013 and June 2017.
- Cytogenetic testing was performed in 89.45% of cases.
- Statistical analysis was conducted using SPSS 21.
Main Results:
- Out of 237 pediatric AML patients, 72 (34%) had core binding factor.
- A significant difference was observed in white cell count and subtypes (p=0.000).
- A significant association was found between core binding factor and AML subtypes (p=0.000).
Conclusions:
- Core binding factor acute myeloid leukaemia is prevalent in the pediatric population studied.
- There is a significant association between core binding factor and specific acute myeloid leukaemia subgroups.
Objective:
To find the frequency of core binding factor acute myeloid leukaemia in our population, and to determine its association with morphological subtypes.
Methods:
The retrospective study was conducted at The Indus Hospital, Karachi, and comprised data of patients aged 1-17 years who were diagnosed with acute myeloid leukaemia from July 2013 to June 2017. Data was analysed using SPSS 21.
Results:
Of the 237 patients, 137(58%) were males and 100(42%) were females. The overall mean age was 8±4.34 years. Cytogenetic testing had been performed in 212(89.45%) cases, and core binding factor was detected in 72(34%) cases. There was significant difference between the mean values of white cell count and the subtypes (p=0.000). Also the difference between core binding factor and the subtypes was significant (p=0.000).
Conclusions:
There was found to be a significant association of core binging factor with specific subgroups of acute myeloid leukaemia.
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