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Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...

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Related Experiment Video

Updated: Nov 20, 2025

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking

Published on: August 6, 2013

Parametric Mapping for TSPO PET Imaging with Spectral Analysis Impulsive Response Function.

Mattia Veronese¹, Marcello Tuosto², Tiago Reis Marques³

¹Department of Neuroimaging, IoPPN, King's College London, London, UK. mattia.veronese@kcl.ac.uk.

Molecular Imaging and Biology

|January 21, 2021

Summary

This summary is machine-generated.

Spectral analysis (SA) impulse response function (IRF) offers robust voxel-wise quantification for translocator protein (TSPO) PET imaging. This noise-robust method accurately reflects TSPO availability and genotype, overcoming limitations of traditional compartmental models.

Keywords:

PET Parametric mapping Spectral analysis TSPO

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Last Updated: Nov 20, 2025

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PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke

Published on: June 14, 2018

Area of Science:

Neuroimaging
Radiochemistry
Pharmacokinetics

Background:

Translocator protein (TSPO) positron emission tomography (PET) quantification is challenging due to heterogeneous TSPO expression and modulation in neuroinflammation.
Traditional compartmental models struggle with noise in voxel-wise PET data, limiting their reliability.
Spectral analysis (SA) offers a noise-robust alternative for parametric mapping and tracer kinetic analysis.

Purpose of the Study:

To evaluate spectral analysis (SA) for voxel-wise quantification of TSPO PET imaging data.
To assess the sensitivity of SA impulse response function (IRF) to TSPO genetic polymorphism, TSPO density, and radiotracer binding affinity.

Main Methods:

Calculated SA impulse response function (IRF) at 90 minutes post-injection as the primary parameter.
Applied SA-IRF to three independent PET studies: TSPO genotype (rs6971) with [11C]PBR28, TSPO density using a blocking study with XBD173, and head-to-head comparison of [11C]PBR28 and [11C]ER176.

Main Results:

SA-IRF generated high-quality parametric maps sensitive to TSPO genotype (25% difference) and availability (39% signal displacement).
Voxel-wise SA-IRF estimates strongly correlated with regional total distribution volume (V_T) from a 2-tissue compartmental model (r=0.86 ± 0.11).
SA-IRF revealed significantly higher estimates for [11C]ER176 compared to [11C]PBR28, consistent with higher specific binding.

Conclusions:

SA-IRF is suitable for voxel-wise quantification of TSPO PET data, producing high-quality maps.
The method demonstrates sensitivity to TSPO availability and genotype.
SA-IRF effectively models TSPO tracer kinetics without requiring additional assumptions.