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Peri-myocarditis caused by topical rectal mesalamine

Benjamin Koslowsky1,2, Amir Orlev3,4

  • 1Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. binyaminkos@szmc.org.il.

Clinical Journal of Gastroenterology
|January 21, 2021
PubMed

Insights

Mesalamine, a medication, can cause peri-myocarditis, an inflammation of the heart lining and muscle. This case highlights the definite link between topical rectal mesalamine and recurrent peri-myocarditis, emphasizing the need for awareness.

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Peri-myocarditis is a known, albeit uncommon, adverse effect associated with mesalamine use.
  • The specific link between topical rectal mesalamine and peri-myocarditis is not widely recognized.

Observation:

  • A 46-year-old male patient experienced recurrent episodes of peri-myocarditis.
  • The patient had a history of repeated exposure to mesalamine.

Findings:

  • A definite association was established between the patient's mesalamine exposure and the development of peri-myocarditis.
  • The recurrent nature of the condition strongly correlated with repeated mesalamine administration.

Implications:

  • Clinicians should consider peri-myocarditis in patients using mesalamine, particularly when using topical rectal formulations.
  • Early recognition and diagnosis of mesalamine-induced peri-myocarditis are crucial to prevent severe cardiac complications.
Keywords:
MesalamineMyocarditisPericarditisTopicalUlcerative colitis

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