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Sodium (23Na) MRI of the Kidney: Basic Concept
James T Grist1, Esben Søvsø Hansen2, Frank G Zöllner3
1Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Methods in Molecular Biology (Clifton, N.J.)
|January 21, 2021
Summary
Sodium magnetic resonance imaging (23Na MRI) noninvasively images renal sodium handling. This technique assesses the corticomedullary sodium gradient, a key indicator of kidney function and disease.
Area of Science:
- Nephrology
- Medical Imaging
- Biomarker Discovery
Background:
- Renal sodium handling is crucial for kidney function.
- Altered corticomedullary sodium distribution indicates renal pathology.
- Sodium handling derangements can be assessed noninvasively.
Purpose of the Study:
- Introduce sodium imaging (23Na MRI) for renal applications.
- Describe existing 23Na MRI methods for renal sodium handling.
- Overview preclinical applications of 23Na MRI in renal research.
Main Methods:
- Utilizing sodium magnetic resonance imaging (23Na MRI).
- Analyzing corticomedullary sodium distribution and gradient.
- Employing noninvasive imaging techniques.
Main Results:
- 23Na MRI enables visualization of renal sodium distribution.
- Assessment of the corticomedullary sodium gradient is feasible.
- Preclinical studies demonstrate the utility of 23Na MRI.
Conclusions:
- 23Na MRI is a valuable tool for measuring renal sodium handling.
- The technique aids in assessing renal function and pathology.
- Standardization efforts are ongoing to improve renal MRI biomarkers.
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