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Steady, Laminar Flow Between Parallel Plates

Steady, Laminar Flow Between Parallel Plates

Understanding steady, laminar flow between parallel plates is essential for analyzing and designing flow in narrow rectangular channels, commonly found in various water conveyance and drainage systems. The Navier-Stokes equations govern fluid motion and are generally challenging to solve due to their nonlinearity. However, simplifications are possible in certain cases, like the steady laminar flow between parallel plates. For this scenario, we assume steady, incompressible, laminar flow.

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Updated: Nov 20, 2025

Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow

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Development and Testing of a Continuous Flow-Electrical-Split-Flow Lateral Transport Thin Separation System

Farhad Shiri¹, Bruce K Gale¹, Himanshu Sant¹

¹Department of Mechanical Engineering, University of Utah, 1495 E 100 S, Salt Lake City, Utah 84112, United States.

Analytical Chemistry

|January 21, 2021

Summary

A novel continuous particle separation device, Flow-Electrical Split-Flow Lateral Transport Thin (Fl-El-SPLITT), enhances separation efficiency for particles and extracellular vesicles. The platinum electrode Fl-El-SPLITT demonstrated superior performance in continuous separation applications.

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Published on: November 23, 2015

Area of Science:

Biotechnology
Nanotechnology
Analytical Chemistry

Background:

Traditional particle separation methods often lack efficiency and scalability.
Continuous separation techniques are crucial for high-throughput biological and chemical analyses.
Existing electrical-SPLITT devices face limitations in achieving high-purity continuous separations.

Purpose of the Study:

To develop and validate a new high-volume, continuous particle separation device.
To investigate the performance of two novel Flow-Electrical Split-Flow Lateral Transport Thin (Fl-El-SPLITT) device architectures.
To demonstrate the capability of Fl-El-SPLITT for separating particles of different sizes and extracellular vesicles.

Main Methods:

Development of two Fl-El-SPLITT device architectures: platinum electrode on a porous membrane and porous graphite electrode under a membrane.
Utilizing direct current or alternating current to control particle motility within the device.
Testing separation efficiency using polystyrene particles (28 nm and 1000 nm) and U87 glioma cell-derived extracellular vesicles.

Main Results:

The graphite Fl-El-SPLITT achieved approximately 60% separation of small vs. large polystyrene particles.
The platinum Fl-El-SPLITT achieved 75% separation of polystyrene particles in a single pass and 26% continuous separation of small extracellular vesicles from medium EVs.
Electrical-SPLITT continuously directed particle motility based on applied voltage, validating continuous El-SPLITT operation.

Conclusions:

The Fl-El-SPLITT device offers enhanced particle separation capabilities compared to purely electrical-SPLITT devices.
The addition of flow to electrical fields streamlines high-throughput continuous separations based on electrophoretic mobility.
This technology holds potential for particle filtration, fluid desalination, and improved analytical processes.