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Adipokines in vascular calcification.

Xuan Xiao1, Yi-Zhang Liu1, Zhe-Bin Cheng2

  • 1Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China; Research Lab for Clinical & Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China; Departments of Clinical Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, People's Republic of China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|January 21, 2021
PubMed
Summary
This summary is machine-generated.

Adipose tissue (AT) releases adipokines that link obesity to vascular calcification. Imbalanced adipokine generation due to AT hypoxia promotes cardiovascular disease progression.

Keywords:
AdipokinesAdipose tissueObesityVascular calcification

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Area of Science:

  • Endocrinology
  • Cardiovascular Biology
  • Metabolic Research

Background:

  • Adipose tissue (AT) functions as an endocrine gland, secreting adipokines that regulate metabolism and inflammation.
  • Adipokines play a role in connecting obesity with cardiovascular diseases, particularly vascular calcification.
  • Chronic hypoxia in AT, stemming from adipocyte hypertrophy, disrupts adipokine balance, promoting vascular issues.

Purpose of the Study:

  • To summarize the influence of key adipokines on vascular calcification formation and progression.
  • To enhance understanding of adipokines in obesity-associated vascular calcification.
  • To inform therapeutic strategies for counteracting obesity-related vascular calcification.

Main Methods:

  • Review of existing scientific literature on adipokines and vascular calcification.
  • Analysis of the mechanisms by which adipokines affect vascular smooth muscle cells (VSMCs) and vascular calcification.
  • Synthesis of information on the role of AT hypoxia in adipokine dysregulation.

Main Results:

  • Adipokines significantly influence the development of vascular calcification.
  • Imbalanced adipokine profiles contribute to VSMC apoptosis, osteogenic differentiation, and inflammation.
  • Hypoxia-induced changes in AT exacerbate vascular calcification.

Conclusions:

  • Adipokines are critical mediators linking obesity to vascular calcification.
  • Targeting adipokine pathways may offer therapeutic avenues for obesity-associated cardiovascular complications.
  • Further research into adipokine function is essential for developing effective treatments.