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Recent trends in cancer therapy: A review on the current state of gene delivery
Esam Bashir Yahya1, Amaal Mohammed Alqadhi2
1School of Industrial Technology, Universiti Sains Malaysia, Penang 11800, Malaysia.
Abstract:
Cancer treatment has been always considered one of the most critical and vital themes of clinical issues. Many approaches have been developed, depending on the type and the stage of tumor. Gene therapy has the potential to revolutionize different cancer therapy. With the advent of recent bioinformatics technologies and genetic science, it become possible to identify, diagnose and determine the potential treatment using the technology of gene delivery. Several approaches have been developed and experimented in vitro and vivo for cancer therapy including: naked nucleic acids based therapy, targeting micro RNAs, oncolytic virotherapy, suicide gene based therapy, targeting telomerase, cell mediated gene therapy, and CRISPR/Cas9 based therapy. In this review, we present a straightforward introduction to cancer biology and occurrence, highlighting different viral and non-viral gene delivery systems for gene therapy and critically discussed the current and various strategies for cancer gene therapy.
Insights
Gene therapy offers revolutionary cancer treatment options by utilizing advanced bioinformatics and genetic science for targeted delivery. This review explores various gene therapy strategies and delivery systems for effective cancer treatment.
Area of Science:
- Oncology
- Molecular Biology
- Biotechnology
Background:
- Cancer treatment remains a critical clinical challenge, necessitating diverse therapeutic strategies based on tumor type and stage.
- Gene therapy presents a promising frontier for revolutionizing cancer treatment paradigms.
- Advancements in bioinformatics and genetic science enable precise identification, diagnosis, and treatment planning through gene delivery.
Purpose of the Study:
- To provide a comprehensive overview of cancer biology and occurrence.
- To highlight diverse viral and non-viral gene delivery systems for therapeutic applications.
- To critically discuss current and emerging strategies in cancer gene therapy.
Main Methods:
- Review of existing literature on cancer biology and gene therapy approaches.
- Categorization and description of various gene delivery systems (viral and non-viral).
- Analysis of specific gene therapy strategies including naked nucleic acids, microRNA targeting, oncolytic virotherapy, suicide gene therapy, telomerase targeting, cell-mediated gene therapy, and CRISPR/Cas9.
Main Results:
- Gene therapy encompasses multiple approaches, including naked nucleic acids, microRNA targeting, oncolytic virotherapy, suicide gene therapy, telomerase targeting, cell-mediated gene therapy, and CRISPR/Cas9.
- Both viral and non-viral vectors are employed for gene delivery in cancer therapy.
- The efficacy and application of these strategies vary depending on cancer type and stage.
Conclusions:
- Gene therapy holds significant potential to transform cancer treatment landscapes.
- A variety of gene delivery systems and therapeutic strategies are under investigation and development.
- Further research and clinical translation are essential to fully realize the benefits of gene therapy for cancer patients.
