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Related Concept Videos

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Related Experiment Video

Updated: Nov 20, 2025

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
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Severity grading system for acute allergic reactions: A multidisciplinary Delphi study.

Timothy E Dribin1, David Schnadower1, Jonathan M Spergel2

  • 1Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

The Journal of Allergy and Clinical Immunology
|January 21, 2021
PubMed
Summary
This summary is machine-generated.

A new severity grading system for acute allergic reactions was developed to standardize management and research. This system aims to improve communication and clinical care for both anaphylactic and nonanaphylactic reactions.

Keywords:
Allergic reactionsDelphianaphylaxisemergency departmentseverity

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Area of Science:

  • Allergy and Immunology
  • Emergency Medicine
  • Clinical Research Methodology

Background:

  • Lack of a standardized severity grading system for acute allergic reactions hinders optimal management and research.
  • Current systems fail to adequately differentiate reaction severity, impacting clinical practice and scientific advancement.

Purpose of the Study:

  • To develop a novel, consensus-based severity grading system for acute allergic and anaphylactic reactions.
  • To create a system applicable in both clinical settings and research environments.

Main Methods:

  • Convened a multidisciplinary panel of 21 allergy and emergency care experts.
  • Utilized Delphi methodology for consensus-building on grading system structure and content.
  • Critically appraised existing severity grading systems to inform development.

Main Results:

  • Developed a consensus severity grading system for acute allergic reactions, ranging from mild to anaphylactic shock.
  • The system is designed to be intuitive for clinical use and discriminative for research purposes.
  • Consensus was achieved on all components of the proposed grading system.

Conclusions:

  • A consensus severity grading system for acute allergic reactions has been successfully developed.
  • International validation and dissemination are crucial for improving provider-patient communication and advancing research.
  • The new system promises to enhance the standardization of allergic reaction management and research.