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Related Concept Videos

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Related Experiment Video

Updated: Nov 20, 2025

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method
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The microbiome links between aging and lupus.

Nurit Katz-Agranov1, Gisele Zandman-Goddard2

  • 1Department of Medicine, Saint Elizabeth's Medical Center, Boston, MA, USA; Tufts University School of Medicine, Boston, MA, USA.

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|January 21, 2021
PubMed
Summary
This summary is machine-generated.

The microbiome, or gut bacteria, shows similar dysbiosis (imbalance) in both aging individuals and lupus patients. These microbial changes contribute to immune system aging and may play a role in lupus development and symptoms.

Keywords:
AgingDysbiosisInflammagingLupusMicrobiomeSLESenescence

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Area of Science:

  • Immunology
  • Microbiome Research
  • Gerontology

Background:

  • Immune dysregulation, inflammaging, and senescence are observed in both aging populations and patients with systemic lupus erythematosus (SLE).
  • The microbiome is increasingly recognized as a key factor in the pathogenesis of immunosenescence in both aging and SLE.

Purpose of the Study:

  • To investigate similarities in microbiome alterations between aging individuals and lupus patients.
  • To explore the role of dysbiosis in the shared clinical manifestations and immunosenescence observed in these groups.

Main Methods:

  • An extensive literature review was conducted using PubMed and Google Scholar.
  • Studies published between 2000-2019 focusing on the microbiome in elderly populations and lupus patients (murine and human models) were analyzed.
  • Keywords included: microbiome, dysbiosis, lupus, elderly, aging, and inflammaging.

Main Results:

  • Both aging and lupus are associated with microbiome dysbiosis, including reduced microbial diversity.
  • Increased abundance of pro-inflammatory microbes (e.g., Proteobacteria, Bacteroidetes) and decreased beneficial microbes (e.g., Firmicutes) were noted in both groups.
  • Compromised intestinal barrier integrity and leakage of microbial components were observed, contributing to inflammation.

Conclusions:

  • Similar microbiome alterations, characterized by dysbiosis, are present in lupus patients and aging individuals.
  • These microbial changes contribute to immunosenescence and may be a shared mechanism in SLE pathogenesis.
  • Understanding these microbiome parallels offers potential therapeutic avenues for both aging and lupus.