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Reporting of Perinatal Outcomes in Probiotic Randomized Controlled Trials. A Systematic Review and Meta-Analysis.
Íñigo María Pérez-Castillo1, Rafael Fernández-Castillo2, Agustín Lasserrot-Cuadrado1
1Andalusian Research, Development and Innovation Plan, CTS 367, University of Granada, 18001 Granada, Spain.
Nutrients
|January 22, 2021
Summary
Probiotic use during pregnancy does not appear to affect perinatal outcomes like birth weight or delivery mode. Further research should standardize reporting of probiotic strains and outcomes for clarity.
Area of Science:
- Perinatal Health
- Microbiology
- Immunology
Background:
- Probiotic use is increasing among pregnant women.
- Potential immune modulation by probiotics raises questions about perinatal safety and efficacy.
Purpose of the Study:
- To systematically review and meta-analyze randomized controlled trials on probiotic supplementation in pregnancy.
- To evaluate the impact of probiotics on reported perinatal outcomes.
Main Methods:
- Systematic review and random-effects meta-analysis of 46 studies, with 25 included in meta-analysis.
- Analysis focused on reporting consistency and effects on perinatal outcomes.
Main Results:
- Reporting of perinatal outcomes was inconsistent; only birth weight, cesarean section, and gestational age were frequently reported.
- Probiotic administration during pregnancy showed no significant positive or negative impact on evaluated perinatal outcomes.
- Strain-level subgroup analyses did not yield significantly different results.
Conclusions:
- Probiotic supplementation during pregnancy does not appear to influence key perinatal outcomes.
- Future studies need standardized reporting of probiotic strains and perinatal outcomes to clarify effects.
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