Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

3.8K
Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
3.8K
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

2.6K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sprayable Hydrogel Dressings in Wound-Healing Applications.

Bioengineering (Basel, Switzerland)·2026
Same author

Tendon dECM Composited with Chitosan with Loading Skin Precursor Stem Cell Exosome for Enhanced Diabetic Wound Healing.

Gels (Basel, Switzerland)·2026
Same author

Development of a Nano-Hybrid Composite Using Bovine Hydroxyapatite and Montmorillonite for Endodontic Applications-An In Vitro Study.

International endodontic journal·2026
Same author

Differential Expressions of Inflammatory, Dentinogenic, Regulatory, Proliferative and Stemness Genes in Non-Carious and Carious Human Dental Pulp Tissues: An Ex Vivo Proof-of-Concept Study.

International endodontic journal·2026
Same author

Quercetin Released Biomedical Hybrid Hydrogels Fabricated by Silk Fibroin and Sodium Alginate with Incorporation of Ag@rGO Nanosheets.

Molecules (Basel, Switzerland)·2026
Same author

Biomedical Interpenetrated Hydrogels Fabricated via Quaternary Ammonium Chitosan and Dopamine-Conjugated Gelatin Integrated with Genipin and Epigallocatechin Gallate.

Gels (Basel, Switzerland)·2026

Related Experiment Video

Updated: Nov 20, 2025

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
09:34

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

9.6K

Advances in Growth Factor Delivery for Bone Tissue Engineering.

Érica Resende Oliveira1, Lei Nie2, Daria Podstawczyk3

  • 1Food Engineering Department, School of Agronomy, Universidade Federal de Goiás, Campus Samambaia, Goiânia CEP 74690-900, Goiás, Brazil.

International Journal of Molecular Sciences
|January 22, 2021
PubMed
Summary
This summary is machine-generated.

Tissue engineering advances bone regeneration by combining polymer scaffolds with controlled growth factor delivery. This integrated approach enhances osteoinduction and angiogenesis for improved bone repair and tissue regeneration.

Keywords:
biomaterialsbioscaffoldbone morphogenetic proteinbone regenerationdrug deliverygrowth factorpolymer compositestissue engineering

More Related Videos

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
12:27

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Published on: August 22, 2016

7.8K
Covalent Binding of BMP-2 on Surfaces Using a Self-assembled Monolayer Approach
10:23

Covalent Binding of BMP-2 on Surfaces Using a Self-assembled Monolayer Approach

Published on: August 26, 2013

14.3K

Related Experiment Videos

Last Updated: Nov 20, 2025

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
09:34

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

9.6K
Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
12:27

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Published on: August 22, 2016

7.8K
Covalent Binding of BMP-2 on Surfaces Using a Self-assembled Monolayer Approach
10:23

Covalent Binding of BMP-2 on Surfaces Using a Self-assembled Monolayer Approach

Published on: August 26, 2013

14.3K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Bone diseases and tissue regeneration present significant clinical challenges.
  • Tissue engineering and regenerative medicine offer solutions through biomimetic scaffolds and signaling molecules.
  • Current approaches often study scaffolding and growth factors separately, limiting regenerative potential.

Purpose of the Study:

  • To review recent advancements in bone regeneration strategies.
  • To focus on integrated approaches combining scaffolding and growth factors.
  • To highlight polymer-based scaffolds for spatiotemporal growth factor delivery.

Main Methods:

  • Review of current literature on bone regeneration.
  • Analysis of polymer-based scaffolds for controlled release.
  • Examination of strategies for single and multiple growth factor delivery.

Main Results:

  • Combined scaffolding and growth factor systems show great potential for bone regeneration.
  • Polymer scaffolds enable spatiotemporal control over growth factor release.
  • Integrated approaches improve osteoinduction and angiogenesis for new bone formation.

Conclusions:

  • Simultaneous consideration of scaffolding and growth factors is crucial for effective bone regeneration.
  • Advanced delivery strategies using polymer scaffolds enhance bone repair outcomes.
  • Continued research in bone tissue engineering is vital for clinical translation and material development.