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Suprabasin-A Review
Miroslav Pribyl1, Zdenek Hodny1, Iva Kubikova1
1Laboratory of Genome Integrity, Institute of Molecular Genetics of the Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic.
Genes
|January 22, 2021
Summary
Suprabasin (SBSN) is a human gene with an unknown function, but its link to cancer suggests a role in tumor development. This review summarizes current knowledge on SBSN
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Suprabasin (SBSN) is a human gene with largely unknown physiological functions.
- SBSN is implicated in various human diseases, notably cancer, prompting research interest.
Purpose of the Study:
- To review and consolidate existing knowledge on suprabasin (SBSN).
- To explore the potential roles and mechanisms of SBSN in both normal physiology and disease states, particularly cancer.
Main Methods:
- Literature review of studies on suprabasin (SBSN).
- Analysis of existing data on SBSN expression and its correlation with disease prognosis.
Main Results:
- Suprabasin (SBSN) expression is associated with poor prognosis in oesophageal carcinoma, glioblastoma multiforme, and myelodysplastic syndromes.
- Three SBSN isoforms encode secreted proteins with potential signaling functions, though their effects are poorly characterized.
Conclusions:
- Suprabasin (SBSN) may play a significant role in human tumorigenesis.
- Further research is needed to elucidate the precise functions and mechanisms of SBSN in health and disease.
