Related Experiment Video
Updated: Nov 20, 2025

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
TNAP as a New Player in Chronic Inflammatory Conditions and Metabolism
Stephanie Graser1, Daniel Liedtke2, Franz Jakob1
1Bernhard-Heine-Center for Locomotion Research, Department of Orthopedics, Julius-Maximilians-University Würzburg, 97076 Würzburg, Germany.
Abstract:
This review summarizes important information on the ectoenzyme tissue-nonspecific alkaline phosphatase (TNAP) and gives a brief insight into the symptoms, diagnostics, and treatment of the rare disease Hypophosphatasia (HPP), which is resulting from mutations in the TNAP encoding ALPL gene. We emphasize the role of TNAP beyond its well-known contribution to mineralization processes. Therefore, above all, the impact of the enzyme on central molecular processes in the nervous system and on inflammation is presented here.
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