Related Experiment Video
Updated: Nov 20, 2025
07:16
Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
Published on: September 13, 2018
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Hippo Signaling Pathway in Gliomas
Konstantin Masliantsev1,2,3, Lucie Karayan-Tapon1,2,3, Pierre-Olivier Guichet1,2,3
1Inserm U1084, Laboratoire de Neurosciences Expérimentales et Cliniques, F-86073 Poitiers, France.
Cells
|January 22, 2021
Summary
The Hippo signaling pathway regulates organ size and is implicated in various cancers. This review synthesizes its role in gliomas, suggesting it as a potential therapeutic target for brain tumors.
Area of Science:
- Cellular signaling pathways
- Cancer biology
- Neuro-oncology
Background:
- The Hippo pathway, a conserved regulator of organ size, involves MST1/2 and LATS1/2 kinases inhibiting YAP/TAZ nuclear translocation.
- Dysregulation of the Hippo pathway is linked to tumorigenesis and metastasis in several cancers.
- Its role in brain tumors, particularly gliomas, remains under-investigated despite poor patient prognosis.
Purpose of the Study:
- To review and synthesize current knowledge on the Hippo signaling pathway's involvement in glioma development.
- To highlight the potential of the Hippo pathway as a therapeutic target for malignant gliomas.
Main Methods:
- Literature review and synthesis of recent advances in Hippo pathway research.
- Analysis of the pathway's components (MST1/2, LATS1/2, YAP/TAZ, TEAD) in the context of glioma biology.
Main Results:
- The Hippo pathway regulates cell proliferation and apoptosis, crucial processes in organ development and cancer.
- Evidence suggests the Hippo pathway's involvement in glioma tumorigenesis and metastasis.
- The pathway's core components and their interactions offer potential therapeutic avenues.
Conclusions:
- The Hippo signaling pathway is a promising area for novel therapeutic strategies against gliomas.
- Further research into the Hippo pathway's function in gliomas is warranted to improve treatment outcomes.
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