Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

2.9K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.9K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.1K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.1K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

25.5K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
25.5K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

4.9K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of compound heterozygous SDHA variants on mitochondrial function in pediatric with neurological disease.

Mitochondrion·2026
Same author

Clinical Heterogeneity and Candidate Biomarkers in <i>POLG</i>-Related Mitochondrial Disease.

Neurology. Genetics·2026
Same author

Exploring Outcome Measures for Mitochondrial Myopathies; Insights From a Longitudinal Study on TK2 Deficiency.

Journal of inherited metabolic disease·2026
Same author

C34T mutation of the AMPD1 gene in an elite white runner.

BMJ case reports·2025
Same author

Cardiovascular involvement in glycogen storage diseases.

Nature reviews. Cardiology·2025
Same author

Comprehensive analysis of GDF15 as a biomarker in primary mitochondrial myopathies.

Molecular genetics and metabolism·2025

Related Experiment Video

Updated: Nov 20, 2025

Retinal Organoid Induction System for Derivation of 3D Retinal Tissues from Human Pluripotent Stem Cells
10:05

Retinal Organoid Induction System for Derivation of 3D Retinal Tissues from Human Pluripotent Stem Cells

Published on: April 12, 2021

6.5K

Hereditary Optic Neuropathies: Induced Pluripotent Stem Cell-Based 2D/3D Approaches.

Marta García-López1, Joaquín Arenas2,3, M Esther Gallardo1,3

  • 1Grupo de Investigación Traslacional con Células iPS, Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12), 28041 Madrid, Spain.

Genes
|January 22, 2021
PubMed
Summary

Induced pluripotent stem cells (iPSCs) offer a new way to study inherited optic neuropathies. iPSC-derived retinal ganglion cells (RGCs) can model these diseases and aid drug discovery for effective therapies.

Keywords:
iPSiPSCsinduced pluripotent stem cellsmitochondriopathyoptic atrophyoptic neuropathiesorganoidsretinal ganglion cellstissue engineering

More Related Videos

Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells
09:47

Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells

Published on: December 9, 2022

4.1K
Author Spotlight: Simple and Efficient Neural Retina Organoid Production for Disease Modeling
05:03

Author Spotlight: Simple and Efficient Neural Retina Organoid Production for Disease Modeling

Published on: December 22, 2023

1.6K

Related Experiment Videos

Last Updated: Nov 20, 2025

Retinal Organoid Induction System for Derivation of 3D Retinal Tissues from Human Pluripotent Stem Cells
10:05

Retinal Organoid Induction System for Derivation of 3D Retinal Tissues from Human Pluripotent Stem Cells

Published on: April 12, 2021

6.5K
Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells
09:47

Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells

Published on: December 9, 2022

4.1K
Author Spotlight: Simple and Efficient Neural Retina Organoid Production for Disease Modeling
05:03

Author Spotlight: Simple and Efficient Neural Retina Organoid Production for Disease Modeling

Published on: December 22, 2023

1.6K

Area of Science:

  • Neuroscience
  • Genetics
  • Stem Cell Biology

Background:

  • Inherited optic neuropathies cause visual impairment through retinal ganglion cell (RGC) degeneration.
  • These genetic disorders stem from mutations in nuclear DNA or mitochondrial DNA (mtDNA), impacting mitochondrial function.
  • Current treatments for optic neuropathies are limited.

Purpose of the Study:

  • To review the application of induced pluripotent stem cell (iPSC) technology for modeling inherited optic neuropathies.
  • To explore the potential of iPSC-derived RGCs for drug screening and therapeutic development.
  • To discuss current 2D and 3D iPSC-based approaches and innovative technologies like tissue engineering and microfluidics.

Main Methods:

  • Review of existing literature on iPSC applications in optic neuropathy research.
  • Analysis of 2D and 3D cell culture models using iPSCs.
  • Consideration of advanced techniques such as tissue engineering and microfluidics.

Main Results:

  • iPSC technology enables the generation of patient-specific RGCs for disease modeling.
  • iPSC-derived RGCs provide a valuable platform for high-throughput drug screening.
  • Integration of tissue engineering and microfluidics enhances the utility of iPSC models.

Conclusions:

  • iPSC-derived RGCs represent a significant advancement in understanding and treating inherited optic neuropathies.
  • This approach holds promise for developing personalized therapies and effective treatments.
  • Future research should focus on refining iPSC models and incorporating innovative technologies for greater therapeutic impact.