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Related Concept Videos

Toxic Reactions: Overview01:26

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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
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Overview of Protein Metabolism01:21

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Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
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Related Experiment Video

Updated: Nov 20, 2025

Clinical Examination Protocol to Detect Atypical and Classical Scrapie in Sheep
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Toxic Wasting Disorders in Sheep.

Jéssica Molín1, Fábio S Mendonça2, Eileen E Henderson3

  • 1Animal Science Department, University of Lleida, Lleida 25198, Spain.

Animals : an Open Access Journal From MDPI
|January 22, 2021
PubMed
Summary

Toxic substances can cause emaciation and ill-thrift in sheep, often mimicking infectious diseases. Identifying exposure history and removing the source are key to diagnosis and treatment.

Keywords:
intoxicationspoisonous plantssheepwasting

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Area of Science:

  • Veterinary Toxicology
  • Sheep Health Management

Background:

  • Infectious and parasitic agents are commonly linked to sheep wasting conditions.
  • Toxic causes are often overlooked, despite causing emaciation and poor performance.
  • Acute intoxications present clear lesions, while chronic exposure leads to insidious ill-thrift.

Purpose of the Study:

  • To review toxic causes of emaciation and ill-thrift in sheep.
  • To highlight clinical signs, lesions, and diagnostic approaches for toxic disorders.
  • To discuss therapeutic strategies for managing intoxication in sheep flocks.

Main Methods:

  • Review of scientific literature on sheep toxicology.
  • Emphasis on clinical presentations and pathological findings.
  • Discussion of diagnostic methods and treatment protocols.

Main Results:

  • Persistent exposure to organic/inorganic toxins causes emaciation and poor condition.
  • Plant-derived toxins, such as pyrrolizidine alkaloids, contribute to ill-thrift.
  • Diagnostic approach heavily relies on establishing a history of exposure.

Conclusions:

  • Toxic substances are significant contributors to wasting diseases in sheep.
  • Early identification of exposure and source removal are critical for treatment.
  • Integrated management strategies are essential for controlling toxic-induced disorders.