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Ellagic Acid-Cyclodextrin Complexes for the Treatment of Oral Candidiasis
Aline da Graça Sampaio1, Aline Vidal Lacerda Gontijo1, Gabriela de Morais Gouvêa Lima1
1Oral Biopathology Graduate Program, São José dos Campos Institute of Science & Technology, São Paulo State University, UNESP, São Paulo 12245-000, Brazil.
Ellagic acid-cyclodextrin complexes show promise for treating oral candidiasis. This antifungal agent effectively reduced fungal biofilms and invasion in vivo, suggesting a potential new therapeutic option.
Area of Science:
- Mycology
- Pharmacology
- Biotechnology
Background:
- Rising global fungal infections and antifungal resistance necessitate novel therapeutic agents.
- Oral candidiasis, often caused by *Candida albicans*, requires effective and safe treatment options.
Purpose of the Study:
- To evaluate the potential of ellagic acid-cyclodextrin complexes (EA/HP-β-CD) as a treatment for oral candidiasis.
- To assess the antifungal activity, cytotoxicity, and in vivo efficacy of EA/HP-β-CD.
Main Methods:
- Assessed the effect of EA/HP-β-CD on *C. albicans* planktonic cells and biofilms.
- Determined the minimal inhibitory concentration (MIC) and cytotoxicity of EA/HP-β-CD.
- Evaluated in vivo efficacy using a murine model of oral candidiasis.
Main Results:
- EA/HP-β-CD demonstrated a minimal inhibitory concentration of 25 µg/mL against *C. albicans*.
- A concentration of 250 µg/mL inhibited 48-hour biofilms and was classified as slightly cytotoxic.
- In vivo studies showed reduced fungal epithelial invasion after EA/HP-β-CD treatment.
Conclusions:
- EA/HP-β-CD exhibits significant antifungal and anti-inflammatory properties.
- The complex effectively reduces the invasive potential of *C. albicans*.
- EA/HP-β-CD represents a promising alternative for managing oral candidiasis.
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