Related Experiment Video

Updated: Nov 20, 2025

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
05:39

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

2.0K

The Association between Serum Hemoglobin and Renal Prognosis of IgA Nephropathy

Tae Ryom Oh1, Su Hyun Song1, Hong Sang Choi1

  • 1Department of Internal Medicine, Chonnan National University Medical School & Hospital, Gwangju 61469, Korea.

Journal of Clinical Medicine
|January 22, 2021
PubMed

Insights

Serum hemoglobin levels impact Immunoglobin A (IgA) nephropathy progression. Higher hemoglobin is linked to reduced risk, particularly in women, highlighting its role in chronic kidney disease prognosis.

Area of Science:

  • Nephrology
  • Internal Medicine
  • Hematology

Background:

  • Immunoglobin A (IgA) nephropathy is a leading cause of chronic kidney disease globally.
  • Anemia is a frequent complication, but its specific impact on IgA nephropathy progression is understudied.
  • Identifying prognostic factors is crucial for managing IgA nephropathy.

Purpose of the Study:

  • To investigate the association between serum hemoglobin levels and the progression of IgA nephropathy.
  • To determine if serum hemoglobin is an independent predictor of renal outcomes in IgA nephropathy patients.

Main Methods:

  • Retrospective analysis of 4326 patients with biopsy-proven IgA nephropathy.
  • Kaplan-Meier survival analysis, log-rank test, and Cox proportional hazards model were used.
  • Primary endpoint: IgA nephropathy progression (dialysis initiation or kidney transplantation).

Main Results:

  • Serum hemoglobin demonstrated a nonlinear relationship with IgA nephropathy progression.
  • Each 1.0 g/dL increase in serum hemoglobin was associated with a 0.87-fold decreased risk of progression.
  • Reduced serum hemoglobin was an independent risk factor for progression specifically in women.

Conclusions:

  • Serum hemoglobin at diagnosis is an independent predictor of IgA nephropathy progression.
  • Lower hemoglobin levels are associated with increased risk of kidney disease progression.
  • Findings suggest potential therapeutic targets for improving renal prognosis in IgA nephropathy.

Keywords:
IgA nephropathyanemiadisease progressionglomerulonephritishemoglobinprognosisrisk factors

More Related Videos

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis04:37

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

1.1K
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.3K

Related Concept Videos

Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
188
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
80
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
204
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
74
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
139
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
442