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The Functions of the Demethylase JMJD3 in Cancer

Anna Sanchez1,2, Fatma Zohra Houfaf Khoufaf1,2, Mouhamed Idrissou1,2

  • 1Department of Oncogenetics, Centre Jean Perrin, CBRV, 63001 Clermont-Ferrand, France.

International Journal of Molecular Sciences
|January 22, 2021
PubMed

Insights

Epigenetic changes, specifically histone methylation (H3K27me3), are crucial in cancer. This review examines the role of JMJD3 and EZH2 in regulating these epigenetic marks and their impact on various cancer types.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Cancer remains a leading global cause of mortality.
  • Epigenetic modifications, influenced by external and internal factors, play a significant role in cancer initiation and progression.
  • Histone modifications, particularly histone 3 lysine 27 trimethylation (H3K27me3), are frequently altered in various cancers.

Purpose of the Study:

  • This review focuses on the epigenetic mark H3K27me3 and its regulators.
  • The primary objective is to explore the role of Jumonji Domain-Containing Protein 3 (JMJD3) in cancer development.
  • To analyze the implications of JMJD3 and H3K27me3 dysregulation across diverse cancer types.

Main Methods:

  • Literature review of scientific studies on JMJD3, EZH2, and H3K27me3 in cancer.
  • Categorization of data based on cancer type to elucidate specific roles.
  • Synthesis of current knowledge on the interplay between epigenetic regulators and tumorigenesis.

Main Results:

  • H3K27me3 is a repressive epigenetic mark often dysregulated in cancer.
  • JMJD3 and Enhancer of zeste homolog 2 (EZH2) are key regulators of H3K27 methylation.
  • Deregulation of JMJD3 is implicated in the development of numerous cancers, including nervous system, prostate, blood, colorectal, breast, lung, liver, ovarian, and gastric cancers.

Conclusions:

  • JMJD3 and its associated epigenetic mark H3K27me3 are critical factors in cancer development.
  • Understanding the role of JMJD3 in H3K27 methylation offers potential therapeutic targets for cancer treatment.
  • Further research into JMJD3's function across different cancer types is warranted.
Keywords:
H3K27me3JMJD3cancersepi-drugs

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