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Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
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Oral Organoids: Progress and Challenges.

X Gao1,2,3,4, Y Wu1,2,3, L Liao1,2,3,4

  • 1State Key Laboratory of Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Journal of Dental Research
|January 22, 2021
PubMed
Summary
This summary is machine-generated.

Oral organoids, 3D structures from stem cells, mimic oral tissues like teeth, salivary glands, and tongue. These models advance understanding of oral development, disease, and regeneration.

Keywords:
culture techniqueregenerationsalivary glandstem cellstonguetooth regeneration

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Area of Science:

  • Biomedical Engineering
  • Developmental Biology
  • Regenerative Medicine

Background:

  • Oral organoids are 3D structures mimicking oral tissues.
  • Recent advancements focus on tooth, salivary gland, and tongue organoids.
  • These models self-organize from stem cells or progenitors.

Purpose of the Study:

  • To review the construction and applications of oral organoids.
  • To highlight their role in studying oral and maxillofacial development and disease.
  • To showcase their potential in regenerative medicine and precision therapeutics.

Main Methods:

  • Self-organization of dental stem/progenitor cells into tooth germ-like organoids.
  • Tissue engineering approaches using scaffolds for tooth organoid construction.
  • 3D culture systems and induced pluripotent stem cell differentiation for salivary gland and tongue organoids.

Main Results:

  • Oral organoids replicate key structures and functions of native oral tissues.
  • Organoids can model diseases like maxillofacial tumors and tooth dysplasia.
  • Applications include studying tooth development, salivary gland regeneration, and tongue cancer therapeutics.

Conclusions:

  • Oral organoid technology is a powerful new paradigm for oral and maxillofacial research.
  • These models facilitate studies on development, pathology, and regeneration.
  • Oral organoids hold promise for personalized medicine and therapeutic development.