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Acupuncture for Hashimoto thyroiditis: study protocol for a randomized controlled trial.

Shanze Wang1, Jiping Zhao1, Weimei Zeng1

  • 1The Department of Acupuncture, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China.

Trials
|January 22, 2021
PubMed
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This summary is machine-generated.

This pilot trial investigates acupuncture for Hashimoto thyroiditis (HT), assessing its feasibility and effectiveness in reducing thyroid antibodies and improving quality of life. Results will guide future research on acupuncture

Area of Science:

  • Integrative and Complementary Medicine
  • Endocrinology
  • Immunology

Background:

  • Hashimoto thyroiditis (HT) incidence is rising, with no specific etiological treatment.
  • Patients experience impaired quality of life due to symptoms, even with normal thyroid hormone levels.
  • Acupuncture is a potential treatment for thyroid diseases, but lacks standardized clinical studies.

Purpose of the Study:

  • To assess the feasibility, efficacy, and safety of acupuncture for Hashimoto thyroiditis.
  • To evaluate the impact of acupuncture on thyroid antibody levels and patient-reported outcomes.
  • To provide evidence for further clinical trials on acupuncture for HT.

Main Methods:

  • A randomized, black-controlled, assessor-blinded pilot trial involving 60 HT patients.
Keywords:
AcupunctureHashimoto thyroiditisPenetration needlingRandomized controlled trials

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  • Experimental group received 16 weeks of penetration needling of Hand-Yangming meridian (PNHM) followed by a 16-week follow-up.
  • Control group had a 16-week observation period followed by 16 weeks of PNHM therapy.

    • Main Results:

    • Primary outcomes include changes in anti-thyroperoxidase antibodies (TPOAb), antithyroglobulin antibodies (TgAb), and thyroid hormones (FT4, FT3, TSH).
    • Secondary outcomes assess quality of life using ThyPRO-39, SF-36, and anxiety/depression via HAD.
    • Data collected at baseline and weeks 8, 16, 24, and 32.

    Conclusions:

    • The study aims to determine if PNHM can reduce thyroid antibodies and improve quality of life in HT patients.
    • Results will inform future research on acupuncture's role in alleviating HT symptoms.
    • This trial provides a foundation for standardized acupuncture protocols in managing HT.